Dr. Jeff Vidt

SPAID – Shar-Pei Autoinflammatory Disorder

SPAID is a term to describe the spectrum of clinical signs due to systemic and persistent inflammation in Chinese Shar-Pei.  All the signs in SPAID are autoinflammatory in nature and are related elevated levels of hyaluronan, a molecule which functions as a danger signal (a DAMP) that triggers the inflammatory response.  SPAID resembles human AID (autoinflammatory disease) that also presents with multiple inflammatory signs.  Many Shar-Pei with SPAID also receive relief from disease by the use of IL-1β inhibitors which suggests a cytokine-driven inflammation and a dysregulation of the innate immune response.  SPAID definitely is linked to increased levels of...

Update on Colchicine Availability.

URL Pharma was recently purchased by Takeda Pharaceuticals, USA. Takeda has chosen to continue the Patient Assistance Program (PAP) extended to the Chinese Shar-Pei owners for Colcrys® (colchicine). The new application form is on my web site Home Page and should be used from now on. Applicants must provide a valid Colcrys® prescription from a licensed veterinarian and must attest that Colcrys® will be used only for their Shar-Pei dog. Applicants who qualify for the program will be able to select a 30-day supply (60 tablets), a 60-day supply (120 tablets) or a 90-day supply (180 tablets) of Colcrys®. It...

The Answer!

  An important paper published March 17, 2011 in the journal PLoS Genetics has given important new information concerning the relationship between hyaluronan (as present in the folds and wrinkles of the Chinese Shar-Pei), FSF and amyloidosis. The link to the article “A Novel Unstable Duplication Upstream of the HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs” is at http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001332 . An international research group at Uppsala University, Sweden and the Broad Institute of MIT and Harvard including Linda Tintle, DVM of Wurtsboro, New York has uncovered a copy number variant mutation...

Lens Luxation Study at the University of Missouri.

Primary lens luxation is an eye problem which is hereditary on the Chinese Shar-Pei. The lens is held in place in the eye by fibers called zonules. If these fibers are weak, not located properly around the circumference of the lens capsule, or break, the lens can fall out of its normal position or “luxate”. The lens typically moves forward against the iris blocking the pupil and interfering with movement of aqueous fluid into the drainage angle which is located around the base of the iris. This can result in an increase in intraocular pressure known as secondary glaucoma which...

Separation Anxiety

The term “Separation Anxiety” is used to describe or explain destructive behavior associated with the fear of being left alone. There are mild forms of separation anxiety, which can generally be treated with behavior modification exercises; and there are severe cases, often requiring medication. We will discuss the symptoms and some common behavior modification techniques here. Reading the signs There are several different behaviors that could signal separation anxiety. Some dogs will eliminate in the house when you leave, even for short periods. Dogs that are left outside will dig giant holes in your garden, or tunnel under a fence....

TRAINING THE CHINESE SHAR-PEI

The first thing you need to know about training your Shar-Pei is to start right away. Puppies are learning from the moment you bring them home; it is always best to start them off learning the good stuff! Puppy kindergarten or socialization classes are a great way to teach your puppy good manners from the start. As an added benefit of puppy class, you will help to build a strong bond with your puppy, which will ensure future training success. Puppy classes will also help your dog to not be so excited or distracted around other dogs and people. Dogs,...

Holiday Hazards

ARE YOU READY FOR THE HOLIDAYS? With the holidays approaching rapidly, there are a few questions that always seem to pop up regarding pets. There is, of course the question of whether or not to get a pet for Christmas, or give one for that matter. There are the safety concerns for the pets we already have, and love dearly. Do we give our furry family members gifts (and if so, what)? Then, there are the good manners we always have to hear about from our relatives, which of course our pets do not possess when the relatives are around....

Nail Trimming

Equipment needed: Nail trimmers and Kwik-Stop® Dog’s nails or claws are meant to be long. In wild canids they are used as tools for digging, ripping, gripping and fighting. In the domesticated dog these functions are no longer useful and long nails lead to problems such as damaging the home environment, causing injury to people, broken nails resulting in bleeding and trouble walking on hard surfaces. When a dog’s nails become too long they interfere with the dog’s gait and as the nails continue to grow, walking will become awkward and painful. In severe cases a dog’s nails can curl...

GIVING MEDICATIONS TO DOGS

All the medications you have been given for your dog are important. Be sure you understand how to give each one. If questions arise once you get home, do not hesitate to contact your veterinarian. First, check the label of your medication(s) for specifics such as whether it should be refrigerated and whether it should be given before or after meals, etc. It is important that you understand when to give your pet its medication. In addition to oral instructions given to you by your veterinarian, written instructions may accompany each medication. Unless otherwise instructed by you vet, start the...

Ear Care – My opinion

Once a Shar-Pei has an ear problem it will always have ear problems. You will not cure the problem, you will only control it through routine ear maintenance. The primary problem with ear cleaning in the Shar-Pei breed centers around inadequate training and lack of control of the dog. If the dog will not let you clean the ears you will not be able to treat the ears. The training process begins in puppyhood and involves discipline and positive reinforcement methods which are beyond the scope of this article. Suffice it to say that you should train you dog as...

Dietary Protein

Much progress has been made in clinical nutrition in the past decade especially in the area of nutrition in the kidney failure patient. This is still an area of controversy between clinicians and nutritionists, but research is providing more insight concerning the role of dietary protein in the management of the kidney failure patient. What I hope to do here is provide a digest of this current state of affairs and let you make your own decisions. There is a link between dietary protein levels and the clinical signs of kidney failure. Once dogs have developed signs of uremia such...

Diet and Your Shar-Pei

The proper diet is very important for the life and health of your Shar-Pei. Most pets become overweight and inactive if they are allowed to choose their own diet. A fat dog is not a healthy dog and will have a greatly decreased lifespan. RECOMMENDATIONS: Puppy diets with or without water are best until the pup is 4-6 months old. Stick with brand name diets such as Iams, Purina, Pedigree and others. Currently I like the puppy diets for large breed puppies made by Eukanuba® (Iams) and Purina. These diets help to maintain a slower growth rate. Don’t feed according...

Bathing

Bathing your puppy or adult dog can prove to be a challenge. There are many questions, techniques and opinions floating around when discussing bathing a dog. Here are some tips for bath time. How often your pet will need a bath depends on the breed and what type of activities the dog is involved in. It’s best to bathe your dog only when your dog is really dirty. Usually when that “doggy smell” starts, it’s time for a bath. Often local cleaning of mud and/or dirt can be done with water – rinsing the feet with a hose or a...