Symmetric Dimethylarginine (SDMA)


  • Symmetric dimethylarginine is a new renal biomarker which can detect kidney disease when approximately 40% function has been compromised.
  • SDMA is released into the circulation during protein degradation.
  • Because it is almost exclusively eliminated via renal filtration it is a good estimate of GFR.
  • SDMA is specific for kidney function.
  • It is not impacted by extrarenal factors like BUN and creatinine.
  • SDMA is an early indicator of kidney disease – it is not increased in animals with other various diseases.
  • It is not dependent on the dog’s lean muscle mass.
  • SDMA should be evaluated with other kidney tests such as BUN, creatinine, urinalysis, UPC ratio, etc.
  • Additional testing for infectious causes of kidney damage/disease is often necessary

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