Symmetric Dimethylarginine (SDMA)
- Symmetric dimethylarginine is a new renal biomarker which can detect kidney disease when approximately 40% function has been compromised.
- SDMA is released into the circulation during protein degradation.
- Because it is almost exclusively eliminated via renal filtration it is a good estimate of GFR.
- SDMA is specific for kidney function.
- It is not impacted by extrarenal factors like BUN and creatinine.
- SDMA is an early indicator of kidney disease – it is not increased in animals with other various diseases.
- It is not dependent on the dog’s lean muscle mass.
- SDMA should be evaluated with other kidney tests such as BUN, creatinine, urinalysis, UPC ratio, etc.
- Additional testing for infectious causes of kidney damage/disease is often necessary