Author: drjwv_writer

The Answer Way back in 1983 we first started recognizing episodic fevers in Shar-Pei often associated with a swollen, painful hock joint. Later on it was observed that an early-onset kidney failure occurred in many of these dogs as well. I remember many individuals, including myself, remarking that this has to be associated with the wrinkles in some way and now we know it does. An important article was recently published in March, 2011, entitled ―A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs‖, Mia Olsson et...

On October 23-25, 2009 I attended the AKC Canine Health Foundation 2009 National Parent Club Health Conference held in St. Louis, Missouri. This was the seventh conference which is held biannually and was sponsored by Nestlé Purina PetCare Company. The purpose of the conference is several-fold. It brings together many of the top researchers in the canine health field to bring the attendees up to speed on their AKC-CHF grant projects. It also allows the various parent club health representatives to catch their vision of the future – future diagnostic tests, future areas of research, and future therapies for canine...

What’s new on the Shar-Pei front? I have not heard anything specific about the NIH (National Institute of Health) study involving FSF. The preliminary information a few months ago indicated the researchers were pretty close to identifying the genes responsible for FSF. Many thanks again to those of you who allowed blood sample for this study to be taken from your dogs. New information indicates FSF is an autoinflammatory disease and most likely represents an inflammatory response dysregulation problem — a problem involving messenger substances (cytokines, chemotactic factors), receptors, inflammatory mediators and cells involved in the inflammatory response. We are...

What’s new on the Shar-Pei front? I have not heard anything specific about the NIH (National Institute of Health) study involving FSF. The preliminary information a few months ago indicated the researchers were pretty close to identifying the genes responsible for FSF. Many thanks again to those of you who allowed blood sample for this study to be taken from your dogs. New information indicates FSF is an autoinflammatory disease and most likely represents an inflammatory response dysregulation problem — a problem involving messenger substances (cytokines, chemotactic factors), receptors, inflammatory mediators and cells involved in the inflammatory response. We are...

Veterinary medicine has changed quite a bit in the last decade with the advent of alternative medicine, three year vaccine protocols, raw food diets, wellness exams, specialty clinics, and other changes. I’ve always tried to advise clients based on my experience with my own dogs, keeping current with the veterinary literature, clinical experience with all the dogs in the practice, new information available on the Internet and talking with colleagues and specialists. I still give my dog’s annual vaccinations which I have been doing for 26 years with no adverse consequences, I know of. I still feed good quality commercial...

GAG Mimetics Amyloid deposits are complex structures where the amyloid fibrils are intertwined with other amyloid proteins called proteoglycans that are always present in the deposits regardless of the type of amyloid fibril present. Proteoglycans, especially the sulfated glycosaminoglycan (PSGAG) molecule portion of specific proteoglycans, have been shown to interact with the amyloidogenic amyloid proteins. These GAGs promote fibril formation. Glycosaminoglycans may affect precursor processing, folding of the amyloidogenic proteins to form a beta-pleated sheet conformation or polymerization and deposition of amyloid fibrils. An increase in the rate of synthesis of glycosaminoglycans in tissues in which amyloidosis developed would argue...

As many of you know I suffered a fractured heel bone at the end of May and have been recovering ever since. I’m still in physical therapy and realize an older body takes longer to heal. I want to thank you for your continued support, well wishes and help during this time. You have been patient in picking up your pets and putting them on the exam table for me, allowing me to sit down to do exams and waiting a little extra time for me to get medications, etc. Your help has been instrumental in my rehabilitation. Likewise I...