Lens Luxation Study at the University of Missouri.
Primary lens luxation is an eye problem which is hereditary on the Chinese Shar-Pei. The lens is held in place in the eye by fibers called zonules. If these fibers are weak, not located properly around the circumference of the lens capsule, or break, the lens can fall out of its normal position or “luxate”. The lens typically moves forward against the iris blocking the pupil and interfering with movement of aqueous fluid into the drainage angle which is located around the base of the iris. This can result in an increase in intraocular pressure known as secondary glaucoma which can result in loss of vision.
When the lens luxates immediate veterinary attention is required to remove the displaced lens and prevent secondary glaucoma and loss of vision. The University of Missouri College of Veterinary Medicine has developed a DNA test for primary lens luxation in the Chinese Shar-Pei. It has been found in the same gene that causes primary lens luxation in other breeds but is caused by a different mutation at this location. Dr. Gary Johnson is requesting blood samples from Shar-Pei to test for the mutation. He suggested that any Shar-Pei with glaucoma should be evaluated for primary lens luxation. The accompanying PDF download has all the necessary information for Shar-Pei owners to participate in the study. Thanks, in advance, for your help in this study.
Jeff Vidt, DVM
Chairman of the Health Committee, CSPCA (4/2010)